Analysis of antigenicity and immunogenicity of five different chemically defined constructs of a peptide

The aim of this study was to compare the antigenicity and the immunogenicity of five constructs of a peptide, including the peptide in single copy, a tandem repeat containing three copies, a copolymer with glutaraldehyde and two constructs based on the MAP (Multiple Antigenic Peptide) model, one containing two copies (MAP-2) and the other, eight copies of the peptide (MAP-8). The peptide used in this test was the 115–131 sequence derived from the rSm28-GST antigen of Schistosoma mansoni.