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Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, no. 13 (1995): 1365-1370
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Abstract
The development of two novel LTD(4) receptor antagonists as clinical candidates for the treatment of asthma is described. The first generation compound, CP-80,798, was found to be a balanced 5-lipoxygenase inhibitor (5-LOI)/LTD(4) antagonist (LTD(4)-A), while the second generation compound, CP-85,958, is a selective LTD(4) antagonist.
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