The 21-Aminosteroid U74389G Enhances Hepatic Blood Flow and Preserves Sinusoidal Endothelial Cell Function and Structure in Endotoxin-Shocked Dogs
Journal of Surgical Research(1999)
摘要
Background. 21-Aminosteroids are potent anti-inflammatory and antioxidant drugs that provide remarkable endothelial protection in different models of tissue ischemia–reperfusion and inflammation. The effects of 21-aminosteroids in sepsis, a highly inflammatory condition leading to panendothelial activation and injury, are largely uninvestigated. We therefore explored the effects of the 21-aminosteroid U74386G on hepatic blood flow, endothelial cell function, and sinusoidal structure in a canine model of fluid-resuscitated, hyperdynamic endotoxic shock.
更多查看译文
关键词
21-aminosteroids,liver,sepsis,nitric oxide,endothelium
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络