HYPOGLYCEMIC AND ANTIDIABETIC EFFECTS OF WITHANIA COAGULANS FRUIT ETHANOLIC EXTRACT IN NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS: EFFECTS OF WITHANIA COAGULANS

The study deals with the effect of ethanolic extract of Withania coagulans fruits on normal and streptozotocin-induced diabetic models. The maximum reduction of 39.2% in fasting blood glucose at 4 h and 39.9% during oral glucose tolerance test at 2 h was observed with the dose of 750 mg/kg in normal rats, whereas the reduction observed was 47.1 and 42.7% in blood glucose levels of sub-and mild diabetic rats, respectively, at 2 h during oral glucose tolerance test with the same dose. Long-term study of severely diabetic rats showed reduction of 48.5 and 52.6% in fasting blood glucose and postprandial glucose levels, respectively, after 30 days of treatment. In addition 75% decrease in urine sugar and 13.08% increase in body weight of treated group was found at the end of the experiment. Trace elements present in the text were identified through laser-induced breakdown spectroscopy.