Infecções humanas causadas por poxvirus relacionados ao vírus vaccinia no Brasil

Since 1999, human infection caused by Orthopoxvirus has been observed in at least eight Brazilian states, with the presence of vesicles that evolve to Pustules and crusts, especially on the hands, arms and face, after contact with cows showing comparable lesions on the udder. in addition to the skin lesions, there have been descriptions of patients with axillary ganglionic reactions that are sometimes painful, along with fever, headache, fatigue, dehydration, anorexia, sudoresis, arthralgia mid muscle pain. The condition evolves over a three to four-week period. Vulvar lesions and transmission within families have also been described. Molecular studies have shown that the poxviruses identified are genetically related to vaccinia virus samples that were used in vaccination campaigns in die past. Clinical specimens from 80 human infections were studied in die laboratory, and orthopoxvirus infections were confirmed in 68 cases. The lesions observed in these patients are presented and die implications of this zoonosis in Brazil are discussed.