Inhibition of human immunodeficiency virus-1 protease by a C2-symmetrical phosphinic acid amide

Anusch Peyman,Konrad Wagner,Karl-Heinz Budt,Jörg Spanig,Dieter Ruppert,Christoph Meichsner,Arno Paessens

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1994）

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摘要

The inhibition of HIV protease with C2-symmetric phosphinic acid based inhibitors is independent of the dissociation grade of the phosphinic acid. The corresponding amides are not only good inhibitors of HIV protease but also inhibit HIV replication in vitro because of their increased lipophilicity.

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关键词

human immunodeficiency,protease

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