The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney

    Hypertension, Volume 54, Issue 2, 2009, Pages 261-269.

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    Keywords:
    prorenin receptor intercalated cell vacuolar h-atpase atp6ap2 prorenin renin-angiotensin system bafilomycinion exchangeimmunohistochemistrymitogen activated protein kinaserenin angiotensin systemMore(3+)

    Abstract:

    The (pro)renin receptor ([P]RR) is a transmembrane protein that binds both renin and prorenin with high affinity, increasing the catalytic cleavage of angiotensinogen and signaling intracellularly through mitogen-activated protein kinase activation. Although initially reported as having no homology with any known membrane protein, other s...More

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