Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.

Bioorganic & Medicinal Chemistry（2010）

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摘要

In this paper we report on the optimization of the thieno[3,2-c]pyrazole series as inhibitors of the Aurora kinases to give a promising lead compound endowed with high potency in in vitro assays and active in vivo in the HL-60 xenograft tumor model.

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关键词

Aurora kinases,Kinase inhibitor,Tumor cell proliferation inhibition,Anti-cancer

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