The discovery and structure–activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase

Matthew G. LaPorte,Tandy L. Draper,Lori E. Miller,Charles W. Blackledge,Lara K. Leister,Eugene Amparo,Alison R. Hussey,Dorothy C. Young,Srinivas K. Chunduru,Christopher A. Benetatos,Gerry Rhodes,Ariamala Gopalsamy,Torsten Herbertz,Christopher J. Burns,Stephen M. Condon

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

We describe the structure–activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.

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关键词

HCV NS5B polymerase,Pyranoindoles

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