Pp.21.329 Epithelial Sodium Channel Y Subunit Polymorphism Influences Arterial Hypertension Emergence in a High Sodium Ingestion Population

Maria Isabel Mendonça,Ana Célia Sousa,Ana Isabel Freitas,A. Pereira,S. Freitas,Atilla Brehm, Jorge J. Araujo,Roberto Palma dos Reis, Miriam Revera, Grzegorz Bilo, Anna R. Giuliano, Gianluca Caldara, Giulio Savia, Veronica Mainini, M. Mencarelli, Lorena Piccinno,A. M. Di Blasio,Alberto Piperno,Antonio Liuzzi,Giusepe Mancia,Gianfranco Parati

Journal of Hypertension（2010）

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摘要

Methods: Case-control study including 613 individuals, 369 of which with essential hypertension (cases) and 244 without hypertension (controls). Cases and controls were matched by sex and age. Biochemical analyses and DNA extraction for genetic analyses were performed in all subjects and the epithelial sodium channel genetic polymorphism (SCNN1A(-173)G) was evaluated in each and every one of them.

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epithelial sodium channel,polymorphism

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