Synthesis and in vivo evaluation of bicyclic gababutins

David C. Blakemore,Justin S. Bryans,Pauline Carnell,Christopher L. Carr,Nicola E.A. Chessum,Mark J. Field,Natasha Kinsella,Simon A. Osborne,Andrew N. Warren,Sophie C. Williams

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A range of bicyclic gababutins were synthesised. Of these compounds (−)-(11A) and (20A) proved to have excellent levels of in vitro potency and were profiled in an in vivo model of neuropathic pain.

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关键词

Gabapentin,Gababutin,Pregabalin,Pain

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