Synthesis, Interaction With Mitochondrial And Cancer Cells Of A Dinuclear Manganese(Ii) Complex: Mn-2(Adpa)(2)Cl-4

A dinuclear manganese(II, II) complex Mn-2(Adpa)(2)Cl-4 (Adpa=N-allyl di(picolyl)amine) was synthesized and the crystal structure was deter-mined using X-ray diffraction crystal structure analysis. The bioassay results show complex was active against the four kinds of cancer cells (HepG 2, Eca-109, LoVo, A549) with IC50 in the range 25 similar to 65 mu mol center dot L-1, and it was found that the complex activated the proliferation of cancer cell A549 in the range of 1 similar to 20 mu mol center dot L-1. The interaction between ct-DNA and complex is weak, but the complex can inhibit the induced swelling of Ca2+-loaded mitochondria swelling in a dose-dependent manner in vitro. CCDC: 658318.