Markovnikov's Rule in History and Pedagogy
Foundations of Chemistry, Volume 4, Issue 1, 2002, Pages 61-72.
Physical ChemistryAddition ReactionEmpirical Rule
In 1870–75 Markovnikov enunciatedan empirical Rule which generalized theregiochemical outcome of addition reactions tounsymmetrical alkenes. This Rule remaineduseful for about 75 years, until suchreactions came to be better understood inmechanistic terms. Thereafter the Rule couldbe deduced from principles of relativecarbocation stabiliza...更多