Adaptive immune defects and delayed rejection of allogeneic tumor cells in beige mice
CELLULAR IMMUNOLOGY(1984)
摘要
The effect of the beige ( bg ) mutation on adaptive allogeneic tumor rejection was examined by monitoring tumor cell survival in vivo using [ 131 I]iododeoxyuridine-prelabeled cells. Accelerated elimination of allogeneic tumor cells normally begins 8 days after ip injection and is due to active immune responses. Two independent mutations to beige on two different inbred backgrounds (C57BL/6J bg J and DBA/2JCo bg 8 J ) were tested, and bg bg mice showed a 1-day delay in immune elimination of allogeneic cells. This delayed rejection was not due to a defect in clearing label from dead cells, nor to an inability to effect antibody-induced killing in vivo . Both humoral and cell-mediated responses against the allogeneic tumor cells were significantly lower in bg bg than in + bg mice.
更多查看译文
关键词
adaptive immunity,immune response,inbred strain
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络