p19ARF Deficiency Reduces Macrophage and Vascular Smooth Muscle Cell Apoptosis and Aggravates Atherosclerosis

Herminia González-Navarro,Yafa Naim Abu Nabah,Ángela Vinué,María J. Andrés-Manzano,Manuel Collado,Manuel Serrano,Vicente Andrés

Journal of the American College of Cardiology（2010）

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摘要

Conclusions Our findings establish a direct link between p19 ARF , plaque apoptosis, and atherosclerosis, and suggest that human genetic variants associated to diminished CDKN2A expression may accelerate atherosclerosis by limiting plaque apoptosis.

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关键词

ARF,CDKN2A,atherosclerosis,apoptosis,macrophage,vascular smooth muscle cell

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