Development of a Penicillin-reactive IgE Screening Platform

Abstract Penicillins are effective for treating bacterial infections in many clinical situations, but in certain cases, they cause allergic reactions varying frommild skin rashes to anaphylactic shock and death. These symptoms,often resemble,those seen in immediate or delayed hypersensitivityreactions, and may be associated with drug specific IgE and/or drug specific T cells. Currently, the laboratory tests include isotope based serum IgE antibody measurement as well as skin test. However, radioisotope allergen specific tests (RAST) are