Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice

Clinical Immunology, pp. 213-225, 2003.

Cited by: 80|Views8
WOS EI

Abstract:

Here we show that Janus kinase (JAK) 3 is an important molecular target for treatment of autoimmune insulin-dependent (type 1) diabetes mellitus. The rationally designed JAK3 inhibitor JANEX-1 exhibited potent immunomodulatory activity and delayed the onset of diabetes in the NOD mouse model of autoimmune type 1 diabetes. Whereas 60% of v...More

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