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1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

Mark J. Mulvihill,Qun-Sheng Ji,Doug Werner,Patricia Beck,Cara Cesario,Andrew Cooke,Matthew Cox,Andrew Crew,Hanqing Dong,Lixin Feng,K.W. Foreman,Gilda Mak,Anthony Nigro,Matthew O’Connor,Lydia Saroglou,Kathryn M. Stolz,Izabela Sujka,Brian Volk,Qinghua Weng,Robin Wilkes

Bioorganic & Medicinal Chemistry Letters（2007）

引用 37|浏览18
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摘要
A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.
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关键词
IGF-IR,IR,Tyrosine kinase inhibitors,Oncology,Imidazopyrazines,Imidazo[1,5-a]pyrazines,Insulin-like growth-factor-I receptor,Insulin receptor
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