A topliss tree analysis of the HIV-protease inhibitory activity of 6-phenyl-4-hydroxy-pyran-2-ones

Bruce A. Steinbaugh,Harriet W. Hamilton,J.V.N. Vara Prasad,Kimberly S. Para,Peter J. Tummino,Donna Ferguson,Elizabeth A. Lunney,C. John Blankley

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1996）

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摘要

In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substituents were made. (C) 1996 Elsevier Science Ltd

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