Synthesis of 3-Aryl-4(3H)-quinazolinones from Anthranilic Acids and Triethyl Orthoformate

Synthetic Communications（2008）

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摘要

A one-step, convenient approach to the synthesis of 3-aryl-4(3H)-quinazolinones by the reaction of anthranilic acid with triethyl orthoformate in the presence of a catalytic amount of concentrated sulfuric acid has been developed. The possible reaction pathway was proposed.

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BIOLOGICAL EVALUATION,RECEPTOR ANTAGONISTS,DERIVATIVES,AGENTS,QUINAZOLINONES,INHIBITORS,ROUTE

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