5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone.
Bioorganic & Medicinal Chemistry Letters（2009）
摘要
The synthesis and in vitro binding of the thiadiazole inhibitors of Hsp90 with Kds up to 5nM.
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关键词
Hsp90,Thiadiazole,Pyrazole,Isothermal titration calorimetry
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