Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints.

Guo-Hua Chu,Minghua Gu,Joel A Cassel,Serge Belanger,Thomas M Graczyk,Robert N DeHaven,Nathalie Conway-James,Mike Koblish,Patrick J Little,Diane L DeHaven-Hudkins,Roland E Dolle

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.

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关键词

Kappa opioid receptor agonists,Analgesic

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