Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association（2022）
摘要
Our finding of changes on peripheral leukocyte surface antigens in AD implicates the deficit in innate immunity. Leukocyte-based biomarkers prove to be both sensitive and practical for AD screening and diagnosis.
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关键词
Alzheimer's disease,CD11c,CD163,CD59,CD91,ROC curve,complement system,innate phagocytosis,leukocyte biomarker,peripheral immune response,receptor for advanced glycation end products (RAGE)
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