Recombinant HCV Variants With NS5A From Genotypes 1–7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-α

    Gastroenterology, pp. 1032-1042, 2011.

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    Keywords:
    virologyffuoligoadenylate synthetasehepatitis c virusinterferon sensitivity determining regionMore(9+)

    Abstract:

    Heterogeneity in the hepatitis C virus (HCV) protein NS5A influences its sensitivity to interferon-based therapy. Furthermore, NS5A is an important target for development of HCV-specific inhibitors. We aimed to develop recombinant infectious cell culture systems that express NS5A from isolates of the 7 major HCV genotypes, and determining...More

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