Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues

Lisa S. Chen,Lei Du-Cuny,Vasupradha Vethantham,David H. Hawke,James L. Manley,Shuxing Zhang,Varsha Gandhi

Biochemical Pharmacology（2010）

引用 18|浏览9

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摘要

Inhibition of polyadenylation by the metabolites of C-8 modified adenosine analogues, 8-chloroadenosine and 8-aminoadenosine. Molecular modeling of 8-Cl-ATP in the active site of poly(A) polymerase.

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关键词

Polyadenylation,Nucleoside analogues,RNA post-transcriptional processing,Molecular modeling,Hematological malignancies

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