Correlation of peripheral arterial compliance and Framingham coronary heart disease risk evaluation

An office-based air plethysmograph, with internal calibration (VasogramTM), was used to measure arterial compliance (AV/AP) at the thigh and calf in a 4 center clinical study, with 342 subjects (males aged 31 to 69 and females aged 41 lo 79). The subjects were stratified into 4 groups according to Framingham Cardiovascular Risk with 38-47 subjects in each gender/risk group. Group 1. Risk 20% or coronary equivalence but no documented coronary artery disease (CAD). Group 4. documented CAD. Arterial compliance was measured at the thigh and calf levels on each subject, on three different occasions, over a four-week period. Compliance was reported as the maximum volume change (ml) under the cuff occurring during a single cardiac cycle, normahzed lo a pulse pressure of 50 mmHg (MaxV50) with mean levels summarized in the table below: POSTER SESSION 1104 Platelets, Endothelium, and Thrombosis I