Indomethacin prevents the induction of inducible nitric oxide synthase in murine peritoneal macrophages and decreases their nitric oxide production

    Life sciences, Volume 68, Issue 16, 2001, Pages 1923-1930.

    Cited by: 22|Bibtex|Views1|Links
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    Keywords:
    nitric oxide synthaseindomethacinnitric oxidemacrophagesinhibition of induction

    Abstract:

    Indomethacin (0.14-.5 mM concentration) inhibits nitric oxide production in murine peritoneal macrophages. This was evidenced by measuring both nitrite production or 14C-L-citrulline formation. The inhibition was caused by the diminution of de novo inducible nitric oxide synthase production as demonstrated by Western blotting experiment. ...More

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