Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.

Bioorganic & Medicinal Chemistry Letters(2001)

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摘要
(E)- and (Z)-5-Desamino huperzine A derivatives have been synthesized using a new synthetic strategy towards the huperzine A skeleton. These derivatives showed AChE inhibition constants in the low micromolar range and thus display better activity than all previously synthesized C5 derivatives.
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