The effect of chloroform ingestion on the growth of some murine tumours

Chloroform was administered to mice in their drinking water at a dose level of either 0.15 or 15 mg/kg/day. At the lower dose level chloroform did not significantly alter the rate of multiplication of the Ehrlich ascites cells. Prolonged intake of chloroform at 0.15 mg/kg significantly increased the Lewis lung tumour protein levels although the growth and metastasis in the chloroform-ingesting animals was not significantly different from the controls. The percentage of animals with organs invaded by B 16 melanoma was increased by chloroform ingestion at 0.15 mg/kg. At the higher treatment level the rate of metastasis of the Lewis lung carcinoma and the number of Ehrlich ascites cells were increased.