Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists
Bioorganic & Medicinal Chemistry Letters(2005)
摘要
The chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH-2), also found on eosinophils and basophils, is a prostaglandin D2 receptor involved in the recruitment of these cell types during an inflammatory response. In this report, we describe the synthesis and optimization of a ramatroban isostere that is a selective and potent antagonist of CRTH-2 which may be useful in the treatment of certain diseases.
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关键词
CRTH-2,Prostaglandin D2,Ramatroban,Asthma
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