The platelet-activating factor antagonist BB-882 does not improve tissue oxygen extraction in endotoxic shock

    Journal of critical care, Volume 13, Issue 2, 1998, Pages 81-90.

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    Abstract:

    We investigated whether BB-882, a novel potent PAF antagonist, could influence systemic and pulmonary hemodynamics and oxygen extraction capabilities during an acute reduction in blood flow induced by cardiac tamponade after endotoxin challenge.Twenty-one anesthetized, ventilated, and endotoxin-shocked (2 mg/kg i.v. Escherichia coli endot...More

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