Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues.

Lei Wang,Ana A Alcaraz,Ruth Matesanz,Chun-Gang Yang,Isabel Barasoain,J Fernando Díaz,Ye-Zhi Li,James P Snyder,Wei-Shuo Fang

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

In combination with chemical modifications, bioassays, and computational simulation techniques, C-2 benzoylthio, and benzylthio taxoids were synthesized, biologically evaluated, and their binding conformations rationalized, in order to probe the interaction of taxane molecule with β-tubulin.

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关键词

Paclitaxel,Taxol analogues,Binding conformation,SAR studies

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