Effects of the endothelin-1 receptor antagonist tezosentan on renal blood flow and diuresis during prolonged increased intra-abdominal pressure.

Fjølnir F Gudmundsson,Asgaut Viste,Ole L Myking,Ketil Grong,Leif Bostad,Knut Svanes

Journal of Surgical Research（2003）

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摘要

Background.It has earlier been shown that increased intra-abdominal pressure (IAP) reduces renal blood circulation and urine output both clinically and experimentally. The aim of this study was to investigate the effect of endothelin-1 inhibition by the endothelin-1 receptor antagonist tezosentan on renal blood circulation and diuresis in pigs subjected to prolonged increased intra-abdominal pressure.

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regional blood flow,renal physiology,renal hemodynamics,abdominal compartment syndrome,microspheres,diuresis,endothelin-1,aldosterone,renin,pigs

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