Structure–activity relationship studies of novel 3-oxazolidinedione-6-naphthyl-2-pyridinones as potent and orally bioavailable EP3 receptor antagonists

Ángel I. Morales-Ramos,Yue H. Li,Mark Hilfiker,John S. Mecom,Patrick Eidam,Dongchuan Shi,Pei-San Tseng,Carl Brooks,David Zhang,Ning Wang,Jon-Paul Jaworski,Dwight Morrow,Harvey Fries,Richard Edwards,Jian Jin

Bioorganic & Medicinal Chemistry Letters（2011）

引用 8|浏览30

暂无评分

摘要

3-Oxazolidinedione-6-napthyl-2-pyridinones are presented as novel and subtype selective EP3 antagonists. The synthesis and extensive SAR that led to the discovery of compound 29 are described.

查看译文

关键词

EP3 receptor,Novel, potent, selective, and orally active antagonists,3-Oxazolidinedione-6-aryl-pyridinones

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要