Interleukin-10-secreting CD4 cells from aged patients with AIDS decrease in-vitro HIV replication and tumour necrosis factor alpha production.

Regis M Andrade,Patrícia G Lima,Renato G S Filho,Joana Hygino,Samantha F Milczanowski,Arnaldo F B Andrade,Catharina Lauria,Rodrigo Brindeiro,Amilcar Tanuri,Cleonice A M Bento

AIDS（2007）

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摘要

Elevated IL-10 production by aged AIDS patients contributed considerably to control of HIV replication and to inhibition of TNF-alpha secretion but not to the reduced IFN-gamma production.

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关键词

aged patient, AIDS, CD4 T cells, cytokines, interleukin-10, HIV-1 replication, interferon-gamma, senescence, T-cell responses, tumour necrosis factor alpha

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