Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands.

Dorota Łazewska,Kamil Kuder,Xavier Ligneau,Jean-Claude Camelin,Walter Schunack,Holger Stark,Katarzyna Kieć-Kononowicz

Bioorganic & Medicinal Chemistry（2009）

引用 12|浏览13

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摘要

New diethers 4–16 were prepared and evaluated for their in vitro binding affinities at human histamine H3 receptor. The 3-methylpiperidine derivative 11 (R1=3-CH3, m=1, n=3, R2=4-Cl) is the most potent compound (Ki value of 3.2nM) in this series.

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关键词

Histamine receptor, H3,Non-imidazole ligands,Homopiperidine,Methylpiperidine

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