Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.

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关键词

Melanocortin subtype-4 receptor,MC4R,Agonist,Spiroindane,Erectile dysfunction

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