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Scaffold Oriented Synthesis. Part 2: Design, Synthesis and Biological Evaluation of Pyrimido-Diazepines As Receptor Tyrosine Kinase Inhibitors.

Vijaya Gracias,Zhiqin Ji,Irini Akritopoulou-Zanze,Cele Abad-Zapatero,Jeffrey R. Huth,Danying Song,Philip J. Hajduk,Eric F. Johnson,Keith B. Glaser,Patrick A. Marcotte,Lori Pease,Nirupama B. Soni,Kent D. Stewart,Steven K. Davidsen,Michael R. Michaelides,Stevan W. Djuric

Bioorganic & Medicinal Chemistry Letters（2008）

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关键词
KDR inhibitors,VEGFR,PDGFR,cKit inhibitors,Flt3 inhibitors,adenine mimics,structure-based drug design
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