Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.

K Shankaran,Karla L Donnelly,Shrenik K Shah,Charles G Caldwell,Ping Chen,William K Hagmann,Malcolm Maccoss,John L Humes,Stephen G Pacholok,Theresa M Kelly,Stephan K Grant,Kenny K Wong

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

The preparation and SAR of a series of iNOS inhibitors leading to the most potent compound, incorporating a (1,4)-5-imino thiazepane (R=n-Pr) is disclosed.

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关键词

NOS synthase

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