4.2. BRCAX BREAST TUMORS COMPRISE A HETEROGENEOUS CLASS, DISTINCT FROM SPORADIC AND BRCA1 BREAST TUMORS BY ARRA Y- CGH, AND MA Y REFLECT MUL T IPLE ETIOLOGIES

E. H. van Beers,R. A. Oldenburg,S. A. Joosse,L. F. A. Wessels,M. J. Ligtenberg,N. Hoogerbrugge,K. Kroeze-Jansema,H. Meijers-Heijboer, F. B. Hogervor,S. Verhoef,P. Devilee,P. M. Nederlof

msra

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摘要

Only about 25% of familial breast cancer is explained by mutations in brca1 and brca2 , fewer by moderate penetrance genes like p53, pten, chek2, atm and palb2

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