Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 Ki=4.7nM) that are potent inhibitors of MMP-13.

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关键词

MMP-13 inhibition,Barbituric acid,Structure-based design

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