Effect of propofol on cytokine,myocardium NF-κB and ICAM-1 in children with CPB heart surgery

Objective:To investigate the effect of propofol on myocardial nuclear factor-Kappa B(NF-κB),intercellular adhesion molecule 1(ICAM-1),serum TNF-α and IL-6 in children with cardiopulmonary bypass(CPB)heart surgery.Methods:The 20 children with congenital heart disease(ASD,VSD)and elective CPB heart surgery were divided into control group(n=10) and propofol anesthesia group(n=10) randomly.The myocardial samples were taken at the time of intubatton pre-CPB and reperfusion 30min to observe the variation of NF-κB、 ICAM-1.The serum TNF-α、IL-6 activity were examined at six different points.Results:There were no differents in TNF-α between two group,but IL-6 was much more in control group after CPB than that in propofol group(P0.05) after surgery.Myocardium NF-κB and ICAM-1 significantly increased in control group at the time of reperfusion 30 min as compared with that of propofol group(P0.05).Conclusion:Propofol can protect the myocardium against ischemia/reperfusion injury through inhibition the activity of myocardium NF-κB and ICAM-1.