Quantitative relationship between guanine O6-alkyl lesions produced by Onrigin™ and tumor resistance by O6-alkylguanine-DNA alkyltransferase

Kimiko Ishiguro,Yong-Lian Zhu,Krishnamurthy Shyam,Philip G. Penketh,Raymond P. Baumann,Alan C. Sartorelli

Biochemical Pharmacology（2010）

引用 29|浏览13

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摘要

A novel AGT assay using [benzene-3H]O6-benzylguanine allows quantification of AGT molecules present in a cell as well as guanine O6-alkyl lesions generated in DNA by Onrigin™ and temozolomide.

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关键词

AGT,3H-BG,O6-BG,IC50,90CE,101MDCE,KS90

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