Effects Of Omeprazole On Plasma Levels Of Raltegravir

Raltegravir, a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has pH-dependent solubility. Raltegravir plasma concentration increases with omeprazole coadministration in healthy subjects; this is likely secondary to an increase in bioavailability attributable to increased gastric pH. Increased gastric pH has been reported in HIV-1 infected individuals, and the effects of omeprazole in this intended population may be diminished. Further investigation is necessary.