Aza-stilbenes as potent and selective c-RAF inhibitors.

Octerloney McDonald,Karen Lackey,Ronda Davis-Ward,Edgar Wood,Vicente Samano,Patrick Maloney,Felix Deanda,Robert Hunter

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

Compound 27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed.

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关键词

Kinase,c-RAF,Aza-stilbene

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