Htr2a Gene Variation Is Involved In Antidepressant Treatment Response
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology(2010)
摘要
Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STAR*D (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STAR*D sample. (C) 2009 Elsevier B.V. and ECNP All rights reserved.
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关键词
HTR2A,Pharmacogenetics,SNP,Treatment response,Major Depression,Association study
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