Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy

Stephanie I. Bettink,Christian Werner,Chia-Hui Chen,Patrick Müller,Stephan H. Schirmer,Katrin L. Walenta,Michael Böhm,Ulrich Laufs,Erik B. Friedrich

Biochemical and Biophysical Research Communications（2010）

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摘要

Inflammation and pro-hypertrophic signaling are important for development and progression of myocardial hypertrophy (LVH) and chronic heart failure (CHF). Here we investigated the relevance of integrin-linked kinase (ILK) for chemokine receptor CXCR4- and angiotensin II type 1-triggered signaling and its regulation and role in cardiac remodeling.

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关键词

Chemokines,Integrin-linked kinase,Rac1,Hypertrophy,Heart failure

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