Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.

Carsten Spanka,Ralf Glatthar,Sandrine Desrayaud,Markus Fendt,David Orain,Thomas Troxler,Ivo Vranesic

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

Novel mGluR5 antagonists have been developed. SAR studies and lead optimizations are described, which result in compound 16m with high efficacy in animal models.

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关键词

Metabotropic glutamate receptor,mGluR5 antagonist,Piperidylamides

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