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Optimization and Structure-Activity Relationship of A Series of 1-Phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of Mk-0873, A Potent and Effective Pde4 Inhibitor

Daniel Guay,Louise Boulet,Richard W. Friesen,Mario Girard,Pierre Hamel,Zheng Huang,France Laliberte,Sebastien Laliberte,Joseph A. Mancini,Eric Muise,Doug Pon,Angela Styhler

Bioorganic & Medicinal Chemistry Letters（2008）

Cited 17|Views35
Key words
PDE4,type 4 phosphodiesterase,1,8-naphthyridin-4-one-3-carboxamides,asthma,COPD,MK-0873
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