Safety and pharmacokinetics of plasma-derived mannose-binding lectin (MBL) substitution in children with chemotherapy-induced neutropaenia

Florine N.J. Frakking,Nannette Brouwer,Marianne D. van de Wetering,Ilona Kleine Budde,Paul F.W. Strengers,Alwin D. Huitema,Inga Laursen,Gunnar Houen,Huib N. Caron,Koert M. Dolman,Taco W. Kuijpers

European Journal of Cancer（2009）

引用 47|浏览12

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摘要

Mannose-binding lectin (MBL)-deficient children with cancer may benefit from substitution of the innate immune protein MBL during chemotherapy-induced neutropaenia. We determined the safety and pharmacokinetics of MBL substitution in a phase II study in MBL-deficient children.

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关键词

Mannose-binding lectin,Phase II trial,Chemotherapy,Pharmacokinetics

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